The Francis Bowes Sayre Sr. Highway or simply the Sayre Highway is a four-to-six lane, , primary national highway that connects Cagayan de Oro, Misamis Oriental to Kabacan, Cotabato. It traverses the provinces of Misamis Oriental, Bukidnon and Cotabato.
The highway's name was Route 3 but was changed to Sayre Highway, in honor of Francis Bowes Sayre, Sr., the U.S. Philippine High Commissioner who spearheaded its construction. It extends southward through central Mindanao for a distance of about , linking the northern and southern arms of Route 1 (Digos–Butuan Highway). This section of the Philippine national highway was constructed during the American occupation of the Philippines.
The parts of the highway are composed of National Route 10 ( N10), a spur route of Asian Highway 26 in the north; and National Route 943 ( N943) in the southern portion of the Philippine highway network.
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